Deciphering the gonadal cell atlas of Monopterus albus and cell fate during sex reversal based on single-cell RNA sequencing
This study provides a comprehensive cellular roadmap of gonadal cell dynamics during sex reversal in Monopterus albus. Our findings unveil the molecular mechanisms underlying germline and somatic cell fate determination, offering novel insights into vertebrate sex reversal and potential therapeutic strategies for disorders of sex development (DSD).
Authors
- Yanhong Luo (ORCID: https://orcid.org/0000-0002-0943-4169)
- Xueya Zhao (ORCID: https://orcid.org/0009-0000-5547-261X)
- Lingbo Yi
- Fuyun Zhu
- Shuqing Liang
- Qingtao Yang (ORCID: https://orcid.org/0009-0007-9971-0676)
- Li Wang (ORCID: https://orcid.org/0000-0001-7692-5067)
- Lun Liu (ORCID: https://orcid.org/0000-0003-3379-6503)
- Haibo Yang (ORCID: https://orcid.org/0000-0001-8144-4444)
- Yu Hou (ORCID: https://orcid.org/0000-0002-7445-3817)
- Ruiying Zhao
- Ye J (ORCID: https://orcid.org/0000-0002-6127-2582)
Institutions
- Zunyi Medical University (CN)
- The Affiliated Yongchuan Hospital of Chongqing Medical University (CN)
- Shenzhen Genoimmune Medical Institute (CN)
- Chongqing University of Technology (CN)
- Chongqing Medical University (CN)
Publication Details
- Journal
- Stem Cell Research & Therapy
- Published
- 2025-12-13
- DOI
- https://doi.org/10.1186/s13287-025-04810-8
- Primary Topic
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Type
- article
- Field-Weighted Citation Impact
- 0.00