Cancer risks in Lynch syndrome carriers: a systematic review and meta-analysis
This is the first meta-analysis providing stratified cancer risk estimates by cancer site, gene, and study design. These findings support gene-specific surveillance strategies, such as initiating colonoscopy at age 30-35 for MSH6 and PMS2 carriers, postponing hysterectomy after 50 y for PMS2 carriers, and delaying oophorectomy after 45 y for MLH1 and MSH2 PV carriers.
Authors
- Pauline Rochefort (ORCID: https://orcid.org/0000-0003-4734-6896)
- Séphora Campoy (ORCID: https://orcid.org/0000-0003-3658-9534)
- Youenn Drouet (ORCID: https://orcid.org/0000-0003-2963-558X)
- Christine Lasset (ORCID: https://orcid.org/0000-0002-8052-5880)
- Valérie Bonadona
Institutions
- Université Claude Bernard Lyon 1 (FR)
- Centre National de la Recherche Scientifique (FR)
- Centre de Recherche en Cancérologie de Lyon (FR)
- Laboratoire de Biométrie et Biologie Evolutive (FR)
Publication Details
- Journal
- JNCI Journal of the National Cancer Institute
- Published
- 2025-12-09
- DOI
- https://doi.org/10.1093/jnci/djaf349
- Citations
- 1
- Primary Topic
- Genetic factors in colorectal cancer
- Type
- article
- Field-Weighted Citation Impact
- 1.47