Determinants of the change in empiric antibiotic therapy upon receipt of microbiological data: results from a nationwide antibiotic resistance and use surveillance programme in Madagascar, the TSARA project
This study based in the TSARA surveillance system in Madagascar highlights the influence of clinical factors and microbiological data on antibiotic therapy adjustments. Broad-spectrum antibiotics were widely used as empiric treatment. Availability of the microbiological results decreased the odds of antibiotic discontinuation.
Authors
- Philippe Vanhems (ORCID: https://orcid.org/0000-0003-3188-1456)
- Mihaja Raberahona (ORCID: https://orcid.org/0000-0001-8857-5834)
- Antso Hasina Raherinandrasana (ORCID: https://orcid.org/0000-0002-8998-9913)
- V. Andriananja
- Saïda Rasoanandrasana
- Christopher Elias (ORCID: https://orcid.org/0000-0003-0752-6964)
- Laurent Raskine
- F-X Babin
- Mamy Jean de Dieu Randria
- Paulin Andrianjakasolo Razanakolona
Institutions
- Université Claude Bernard Lyon 1 (FR)
- École Normale Supérieure de Lyon (FR)
- Centre National de la Recherche Scientifique (FR)
- University of Antananarivo (MG)
- Inserm (FR)
- Fondation Mérieux (FR)
- Centre International de Recherche en Infectiologie (FR)
Publication Details
- Journal
- Journal of Hospital Infection
- Published
- 2025-12-13
- DOI
- https://doi.org/10.1016/j.jhin.2025.09.025
- Primary Topic
- Antibiotic Use and Resistance
- Type
- article
- Field-Weighted Citation Impact
- 0.00