Mesenchymal stem cell therapy for radiation-induced xerostomia: a systematic review and network meta-analysis
MSC transplantationresults in a statistically significant but clinically marginal improvement in UWS for RIX, with no significant increase in SAE. The current evidence does not support the superiority of MSC therapy over conventional management. Future large-scale trials are required to determine if optimized MSC strategies can achieve clinically meaningful benefits.
Authors
- Jukun Song (ORCID: https://orcid.org/0000-0003-2542-9340)
- Shen‐sui Li (ORCID: https://orcid.org/0000-0003-1305-7551)
- Zhenglong Tang (ORCID: https://orcid.org/0000-0001-6309-0486)
- Xudong Tian (ORCID: https://orcid.org/0000-0002-7584-6102)
- Yadong Wu
- Weili Wang (ORCID: https://orcid.org/0000-0002-8642-3447)
Institutions
- Guiyang Medical University (CN)
- Affiliated Hospital of Guizhou Medical University (CN)
Publication Details
- Journal
- Stem Cell Research & Therapy
- Published
- 2025-12-13
- DOI
- https://doi.org/10.1186/s13287-025-04824-2
- Primary Topic
- Oral health in cancer treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00