Association between triglyceride–glucose muscle-loss index (TyG–MLI) and incident cardiovascular disease: a prospective cohort study in the UK biobank
TyG-MLI, a composite marker reflecting insulin resistance and muscle loss, was independently associated with incident CVD in this large population-based cohort. These findings suggest that TyG-MLI captures cardiometabolic risk beyond traditional measures and may be particularly informative in individuals without obesity.
Authors
- Sizhuang Huang
- Haihua Zhang (ORCID: https://orcid.org/0000-0003-1651-5167)
- Hao Zhang (ORCID: https://orcid.org/0000-0002-4582-2556)
- Mingyang Li (ORCID: https://orcid.org/0000-0002-4683-4815)
- Mengyue Yu (ORCID: https://orcid.org/0000-0003-3004-8948)
- Yanwen Fang (ORCID: https://orcid.org/0000-0003-1102-2267)
- Weixian Yang (ORCID: https://orcid.org/0009-0002-5394-6927)
Institutions
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Peking Union Medical College Hospital (CN)
- Fu Wai Hospital (CN)
Publication Details
- Journal
- Cardiovascular Diabetology
- Published
- 2025-12-13
- DOI
- https://doi.org/10.1186/s12933-025-03031-w
- Primary Topic
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Type
- article
- Field-Weighted Citation Impact
- 0.00