Injection-site pain after long-acting rilpivirine: No association with tempering time in a prospective observational study
In this real-world cohort, tempering time of RPV-LA was not independently associated with injection-site pain. Age was the only consistent predictor of pain intensity. These findings suggest that strict adherence to tempering recommendations may not substantially influence patient comfort. Further randomized studies are warranted to confirm these observations and explore additional strategies to minimize injection-site discomfort.
Authors
- Vicente Estrada (ORCID: https://orcid.org/0000-0002-7795-5986)
- María José Núñez-Orantos (ORCID: https://orcid.org/0000-0002-6715-590X)
- Noemí Cabello‐Clotet (ORCID: https://orcid.org/0000-0001-7259-554X)
- Juncal Pérez‐Somarriba (ORCID: https://orcid.org/0000-0002-9623-5781)
- Adrián Valls Carbó (ORCID: https://orcid.org/0000-0002-4831-1276)
- Javier Rodríguez-Añover
- Carolina Olmos‐Mata (ORCID: https://orcid.org/0009-0001-9037-4377)
- Sergio Sabogal
- Teresa Martínez-Burgoa
Institutions
- Hospital Clínico San Carlos (ES)
- Centro de Investigación en Red en Enfermedades Cardiovasculares (ES)
- Madrid Health Service (ES)
Publication Details
- Journal
- International Journal of Infectious Diseases
- Published
- 2025-12-11
- DOI
- https://doi.org/10.1016/j.ijid.2025.108310
- Primary Topic
- Pediatric Pain Management Techniques
- Type
- article
- Field-Weighted Citation Impact
- 0.00