Performance of diagnostic procedures for bubonic plague in endemic settings in Madagascar: a prospective test accuracy sub-study within the IMASOY trial
PCR outperforms culture, the previous reference standard. While serology adds diagnostic value, it is impractical for routine use. The F1RDT done on site cannot be relied upon for clinical case management decisions. F1RDT performs better under laboratory conditions and could be implemented in peripheral laboratories for surveillance purposes in resource-constraint settings.
Authors
- Voahangy Andrianaivoarimanana (ORCID: https://orcid.org/0000-0003-1550-3869)
- Mihaja Raberahona (ORCID: https://orcid.org/0000-0001-8857-5834)
- Josephine Bourner (ORCID: https://orcid.org/0000-0003-4687-8380)
- Minoarisoa Rajerison (ORCID: https://orcid.org/0000-0002-0389-9280)
- Rivo Andry Rakotoarivelo (ORCID: https://orcid.org/0000-0003-3438-8624)
- Beza Ramasindrazana (ORCID: https://orcid.org/0000-0002-8838-949X)
- Tansy Edwards (ORCID: https://orcid.org/0000-0002-6110-014X)
- Piero Olliaro (ORCID: https://orcid.org/0000-0003-1426-3680)
- Peter Horby (ORCID: https://orcid.org/0000-0002-9822-1586)
- Reziky Tiandraza Mangahasimbola (ORCID: https://orcid.org/0000-0002-6531-8736)
- Elise Pesonel (ORCID: https://orcid.org/0009-0009-0133-5009)
- Théodora Mayouya-Gamana
- Gabriella Zadonirina
- Rindra Vatosoa Randremanana
- Mamy Jean de Dieu Randria
- Lisy Hanitra Razananaivo
- Salohiniana Manuel Randriamanantena
Institutions
- University of Antananarivo (MG)
- Liverpool School of Tropical Medicine (GB)
- Nuffield Orthopaedic Centre (GB)
- London School of Hygiene & Tropical Medicine (GB)
- Université de Fianarantsoa (MG)
- Institut Pasteur de Madagascar (MG)
Publication Details
- Journal
- Clinical Microbiology and Infection
- Published
- 2025-12-11
- DOI
- https://doi.org/10.1016/j.cmi.2025.12.002
- Primary Topic
- Yersinia bacterium, plague, ectoparasites research
- Type
- article
- Field-Weighted Citation Impact
- 0.00