Brain assembloids decode human cortical networks in Rett syndrome
Tenreiro et al.<sup>1</sup> employ human cerebral organoids and telencephalic assembloids to reveal that MeCP2 deficiency leads to multiple defects in the formation of cortical neuronal networks during early prenatal brain development, offering new insights into the pathology of Rett syndrome.
Authors
- Yangfei Xiang (ORCID: https://orcid.org/0000-0002-6256-6312)
- Sisi Chen (ORCID: https://orcid.org/0000-0001-9448-9713)
Institutions
- ShanghaiTech University (CN)
Publication Details
- Journal
- Cell Reports
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1016/j.celrep.2025.116709
- Primary Topic
- Genetics and Neurodevelopmental Disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00