Histopathologic evidence of VEGF in early neovascular AMD: from a 1992 hypothesis to a 1994 discovery — a historical perspective

The 1992-1994 work established both the hypothesis and the first direct tissue evidence linking VEGF to early nAMD. This discovery, made just over a decade before the advent of anti-VEGF therapy, anticipated one of ophthalmology's most transformative achievements, preserving vision for millions worldwide.