Fibroblast growth factor signals drive the metastatic behavior in small cell lung cancer
The FGF/R axis is a key driver of SCLC metastatic spread in the YAP1-dominant subtype. These data might facilitate the development of potential future therapies targeting FGF/R signalling to prevent SCLC progression and metastasis.
Authors
- Caterina Sturtzel (ORCID: https://orcid.org/0000-0003-1002-5634)
- Lilla Horváth (ORCID: https://orcid.org/0000-0002-2089-1440)
- Andrea Wenninger-Weinzierl (ORCID: https://orcid.org/0000-0001-5984-7714)
- Anna Solta (ORCID: https://orcid.org/0000-0002-5164-010X)
- Beáta Szeitz (ORCID: https://orcid.org/0000-0001-6414-0537)
- Martin Distel (ORCID: https://orcid.org/0000-0001-5942-0817)
- Abigail J. Deloria (ORCID: https://orcid.org/0000-0003-0380-4971)
- Michael Grusch (ORCID: https://orcid.org/0000-0001-5486-9340)
- Karin Schelch (ORCID: https://orcid.org/0000-0001-8742-1737)
- Zsolt Megyesfalvi (ORCID: https://orcid.org/0000-0001-8552-6500)
- Balázs Döme (ORCID: https://orcid.org/0000-0001-8799-8624)
- Büsra Ernhofer (ORCID: https://orcid.org/0009-0008-2409-6402)
- Clemens Aigner (ORCID: https://orcid.org/0000-0002-7787-991X)
- Kristiina Boettiger (ORCID: https://orcid.org/0009-0001-0602-5597)
- Melinda Rezeli (ORCID: https://orcid.org/0000-0003-4373-5616)
- Lisa Glatt
- Julia Sinner
Institutions
- Semmelweis University (HU)
- Primary Children's Hospital (US)
- Lund University (SE)
- Huntsman Cancer Institute (US)
- Comprehensive Cancer Center Vienna (AT)
- National Institute of Oncology (HU)
- St Anna Children's Hospital (AT)
- Országos Korányi Tbc és Pulmonológiai Intézet (HU)
- St. Anna Children's Cancer Research Institute
- Medical University of Vienna (AT)
Publication Details
- Journal
- British Journal of Cancer
- Published
- 2025-12-13
- DOI
- https://doi.org/10.1038/s41416-025-03276-y
- Primary Topic
- Fibroblast Growth Factor Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Austrian Science Fund
- Universität Wien
- Magyar Tudományos Akadémia
- Medizinische Universität Wien
- Innovációs és Technológiai Minisztérium