Immunohistochemical evaluation of T cell receptor and T cell receptor beta constant 1 expression distinguishes benign and neoplastic immature T-cell populations and reveals discrete TRBC1/TCR phenotypes
T-LL showed restricted patterns of TRBC1 expression by IHC, whereas benign immature T-cell populations showed polytypic staining. The observed TCR and TRBC1 phenotypes of T-LL are distinct from those of mature T-cell neoplasms and warrant further study.
Authors
- Elizabeth L. Courville (ORCID: https://orcid.org/0000-0003-0528-9029)
- Jeffrey W. Craig (ORCID: https://orcid.org/0000-0003-1295-3258)
- Margaret E. Moore (ORCID: https://orcid.org/0000-0001-9149-5384)
- Sahil Chaudhary (ORCID: https://orcid.org/0009-0003-2512-8158)
- Vanessa Smith (ORCID: https://orcid.org/0000-0002-0431-503X)
Institutions
- University of Virginia Health System (US)
- University of Virginia (US)
Publication Details
- Journal
- Journal of Hematopathology
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1007/s12308-025-00674-2
- Primary Topic
- Cutaneous lymphoproliferative disorders research
- Type
- article
- Field-Weighted Citation Impact
- 0.00