Intracranial stenosis and longitudinal progression of Alzheimer's disease pathologies
Intracranial stenosis at baseline predicts 4-year increase in amyloid beta deposition. Two or more stenotic intracranial arteries are linked to 2-year tau accumulation. Associations remain after adjusting for apolipoprotein E ε4 status and cognitive impairment. Intracranial atherosclerosis may accelerate both amyloid and tau accumulation.
Authors
- Gijung Jung (ORCID: https://orcid.org/0000-0001-5952-3373)
- Keon Wook Kang (ORCID: https://orcid.org/0000-0003-2622-9017)
- Hyojin Nam (ORCID: https://orcid.org/0000-0003-0456-6100)
- Yun‐Sang Lee (ORCID: https://orcid.org/0000-0003-1640-2090)
- Min Soo Byun (ORCID: https://orcid.org/0000-0003-3159-4510)
- Chanrim Park
- Dahyun Yi (ORCID: https://orcid.org/0000-0002-0860-0946)
- Chul‐Ho Sohn (ORCID: https://orcid.org/0000-0003-0039-5746)
- Juneyoung Lee (ORCID: https://orcid.org/0000-0001-8073-9304)
- Joon Hyung Jung
- Hyejin Ahn (ORCID: https://orcid.org/0000-0002-5759-8969)
- Yoon‐Keun Kim (ORCID: https://orcid.org/0000-0001-7610-7654)
- Dong Young Lee (ORCID: https://orcid.org/0009-0006-0924-6607)
Institutions
- Seoul National University (KR)
- New Generation University College (ET)
- Seoul National University Hospital (KR)
- SNUH SMG-SNU Boramae Medical Center (KR)
- Chungbuk National University Hospital (KR)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/alz.71010
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Research Foundation
- Seoul National University
- Korea Health Industry Development Institute
- National Research Foundation of Korea
- Seoul National University Hospital