Toxic Impacts of Trichlorfon on Tambaqui (Colossoma macropomum): Molecular Evidence of Oxidative, Metabolic and Apoptotic Stress
Trichlorfon triggers a multifaceted toxic response characterized by initial activation of compensatory pathways (stress response, antioxidant defense, and anti-apoptotic mechanisms) followed by late-phase metabolic collapse, mitochondrial hypoxia, and inflammation, with both time- and dose-dependent effects. These findings demonstrate that even sublethal concentrations disrupt hepatic homeostasis and support the use of these genes as molecular biomarkers for environmental monitoring in aquaculture.
Authors
- Hallana Cristina Menezes da Silva (ORCID: https://orcid.org/0000-0002-8998-0855)
- André Gentil da Silva
- Wallice Paxiúba Duncan (ORCID: https://orcid.org/0000-0002-1279-7163)
- Daniele Aparecida Matoso (ORCID: https://orcid.org/0000-0001-7346-6352)
- Roberto Ferreira Artoni (ORCID: https://orcid.org/0000-0002-2528-9846)
- Alves Gomes (ORCID: https://orcid.org/0000-0002-3916-6863)
Institutions
- Universidade Federal do Amazonas (BR)
- Universidade Estadual de Ponta Grossa (BR)
Publication Details
- Journal
- Biology
- Published
- 2025-12-13
- DOI
- https://doi.org/10.3390/biology14121781
- Primary Topic
- Environmental Toxicology and Ecotoxicology
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Conselho Nacional de Desenvolvimento Científico e Tecnológico