Frailty Syndrome and Cardiovascular Diseases in Older People

<b>Objective:</b> Cardiovascular diseases have a high prevalence among the elderly, together with frailty syndrome, and both conditions negatively affect quality of life and limit patient autonomy. This study aimed to explore potential relationships between cardiovascular and metabolic parameters, renal function, and frailty domains to identify potential intervention targets. <b>Methods:</b> A cross-sectional study was conducted between January 2024 and April 2025 at the National Institute of Gerontology and Geriatrics "Ana Aslan", including 359 patients aged over 40 years. Demographic, anthropometric, and clinical data were collected through interviews, medical records, and standardized assessments of frailty components (weakness, exhaustion, slow gait, balance impairment, reduced activity, cognitive decline, and weight loss), as well as cardiovascular diseases and comorbidities. <b>Results:</b> Most participants were aged 65-79 years. ROC curve identified triglycerides as a good indicator of both alcohol consumption (AUC = 0.631, <i>p</i> = 0.042) and smoking status (AUC = 0.676, <i>p</i> = 0.004), while HDL cholesterol showed an inverse association with smoking status (AUC = 0.356, <i>p</i> = 0.019). Reduced renal function was significantly associated with smoking status, balance, gait impairment, and reduced functional mobility. The Up and Go Test indicated a good discriminatory ability for renal function decline (AUC = 0.656, <i>p</i> < 0.001). Muscle strength, MMSE, and Tinetti scores showed inverse associations with renal function. <b>Conclusions:</b> Renal impairment appears to be a reliable indicator across multiple frailty domains, acting as an accelerator of frailty progression. Triglycerides reflect lifestyle-related factors, while the Up and Go Test may serve as a practical screening tool for renal dysfunction in frail older adults. These findings suggest the need to adapt traditional cardiovascular risk management to the frail geriatric population.