Characterization of phenobarbital pharmacokinetics and dosing in adults receiving extracorporeal membrane oxygenation
In adult ECMO patients, phenobarbital's Vd normalized to TBW, was consistent with critically ill non-ECMO patients. Obesity affected Vd, CVVH influenced maintenance dosing, but ECMO decannulation did not impact phenobarbital concentrations.
Authors
- Christina Jacob (ORCID: https://orcid.org/0009-0009-0798-8799)
- Ty Bullard (ORCID: https://orcid.org/0000-0001-6612-2236)
- Natasha Lopez (ORCID: https://orcid.org/0000-0002-6646-8680)
Institutions
- Boston Medical Center (US)
- Massachusetts General Hospital (US)
Publication Details
- Journal
- The International Journal of Artificial Organs
- Published
- 2025-12-14
- DOI
- https://doi.org/10.1177/03913988251398850
- Primary Topic
- Mechanical Circulatory Support Devices
- Type
- article
- Field-Weighted Citation Impact
- 0.00