Two new <i>α</i> -pyrone derivatives from the marine-derived <i>Streptomyces</i> sp. SYPHU 0003
Four <i>α</i>-pyrone derivatives (<b>1-4</b>) were isolated from marine-derived <i>Streptomyces</i> sp. SYPHU 0003, among which two new compounds (<b>1</b> and <b>2</b>). The structures and absolute configurations of compounds <b>1-4</b> were established by comprehensive spectroscopic analyses (MS and NMR), combined with ECD calculations and modified Mosher's method. Antibacterial activity revealed that compounds <b>1-4</b> exhibited identical activity against <i>Acinetobacter baumannii</i> with the MIC values of 64 μg mL<sup>-1</sup>.
Authors
- Huanzhang Xia (ORCID: https://orcid.org/0000-0003-1114-6833)
- Pengyun Mou
- Tingting Tian (ORCID: https://orcid.org/0000-0001-8767-091X)
- Yuan Peng (ORCID: https://orcid.org/0000-0002-6163-9532)
- Xianpu Ni (ORCID: https://orcid.org/0000-0002-5666-3271)
Institutions
- Shenyang Pharmaceutical University (CN)
- Guangxi University (CN)
- Guangxi Veterinary Research Institute (CN)
Publication Details
- Journal
- Natural Product Research
- Published
- 2025-12-14
- DOI
- https://doi.org/10.1080/14786419.2025.2602039
- Primary Topic
- Microbial Natural Products and Biosynthesis
- Type
- article
- Field-Weighted Citation Impact
- 0.00