Non‐Invasive and Rapid Quantitative Elasticity Analysis of Seborrheic Keratosis Based on Optical Coherence Elastography: An Exploratory Study

Seborrheic keratosis is a common benign skin tumor. None of the current conventional testing techniques can assess the mechanical properties of the tissue, such as hardness, elasticity and viscoelasticity. In this study, we investigated the morphological and elastic properties of seborrheic keratosis (SK), a common benign skin tumor, using optical coherence elastography (OCE). We found that the OCE technique was able to distinguish SK tissue from normal tissue. In addition, by measuring skin elasticity, it was possible to identify SK lesions with different clinical types and dermoscopic patterns of presentation. As a non-invasive quantitative tool, OCE demonstrates significant potential in the clinical diagnosis and assessment of skin aging diseases, providing objective evaluations based on elasticity.