Taurine-Modified Gossypol Exerts Dual Anti-Hepatocellular Carcinoma Effects by Inactivating PI3K/AKT Pathway and Targeting FASN-Mediated Lipid Metabolism in Regulatory T Cells
GT exerts synergistic anti-HCC effects through a dual mechanism: directly suppressing tumor proliferation by inactivating the PI3K/AKT pathway, and remodeling the TIME by targeting FASN-dependent lipid metabolism in Tregs. These findings highlight the potential of GT as a novel multitargeted agent for HCC treatment.
Authors
- Wenshuai He (ORCID: https://orcid.org/0009-0004-2348-2740)
- Guoyi Deng (ORCID: https://orcid.org/0009-0001-4741-0811)
- Fasheng Wu
- Jiaxing Sheng (ORCID: https://orcid.org/0009-0006-6401-4796)
- Jichan Shi (ORCID: https://orcid.org/0000-0001-9421-2706)
- Wenya Liu
- Xiaohu Lin (ORCID: https://orcid.org/0000-0001-5136-0397)
- Long Kou
- Jia Hu
- Yajing Lin
Institutions
- Guangxi University of Chinese Medicine (CN)
- Ruikang Affiliated Hospital of Guangxi Medical University (CN)
Publication Details
- Journal
- Journal of Hepatocellular Carcinoma
- Published
- 2025-12-01
- DOI
- https://doi.org/10.2147/jhc.s572305
- Primary Topic
- Research in Cotton Cultivation
- Type
- article
- Field-Weighted Citation Impact
- 0.00