Analysis of the value of transvaginal color Doppler ultrasound parameters combined with systemic immune-inflammation index in predicting the risk of lymph node metastasis in cervical cancer

Background: The study aimed to explore the predictive value of transvaginal color Doppler ultrasound parameters combined with the systemic immune-inflammation index (SII) in assessing the risk of lymph node metastasis in cervical cancer. Methods: A total of 172 patients diagnosed with cervical cancer from January 2016 to January 2024 were enrolled, and divided into a lymph node metastasis group (56 cases) and a non-lymph node metastasis group (116 cases) based on biopsy results as the gold standard. Clinical data, transvaginal color Doppler ultrasound parameters, and SII were compared between the two groups. Variables showing significantly different values were selected to construct a logistic model, and the diagnostic performance was analyzed using the receiver operating characteristic (ROC) curve. Results: Logistic regression analysis identified Lymph Node Short-axis Diameter (SAD), tumor length-to-short-axis diameter ratio (LS) <2, peak systolic velocity (PSV), and SII as the independent risk factors for lymph node metastasis in cervical cancer patients. The transvaginal ultrasound pulsatility index (PI) and resistance index (RI) were protective factors. The predictive model incorporating SAD, LS, PSV, PI, RI, and SII achieved an area under the ROC curve (AUC) of 0.946, with a Youden index of 0.762, and sensitivity and specificity of 85.70% and 95.00%, respectively. Conclusions: The risk prediction model integrating transvaginal color Doppler ultrasound parameters and SII demonstrates high predictive value for cervical cancer lymph node metastasis, suggesting a valuable clinical application potential.