A review on the extraction, separation, purification, detection of flavonoids from aging Citri Reticulatae Pericarpium and its beneficial effects on spleen deficiency

Citri Reticulatae Pericarpium (CRP) plays beneficial effects on regulating Qi and strengthening spleen, drying dampness, and resolving phlegm in traditional Chinese medicine. This review centered on the advantageous impacts of flavonoids regarding spleen deficiency as well as their extraction, separation, and purification procedures, aiming to disclose the characteristics manifested in spleen deficiency conditions. The existing literature has not merely shed light on the therapeutic mechanisms underlying CRP flavonoids within the digestive tract, but has also highlighted their cooperative and amplifying impacts on other organs. By integrating these diverse strands of research, a more in-depth understanding of the pharmacological actions of CRP has emerged, providing a fresh theoretical framework for deciphering the scientific significance of aged CRP.