High‐throughput proteomics uncovers molecular clusters and biomarkers of severity in bullous pemphigoid
CCL13 was among the most prominent inflammatory proteins identified in bullous pemphigoid. The emergence of two distinct skin proteomic clusters highlights a biological heterogeneity of bullous pemphigoid, indicating the need for endotype-driven, personalized treatment strategies.
Authors
- Martina D’Onghia (ORCID: https://orcid.org/0000-0001-8315-3413)
- J. R. Serra
- Carlo Pipitò (ORCID: https://orcid.org/0000-0001-5211-8228)
- Laura Calabrese (ORCID: https://orcid.org/0000-0001-5238-2336)
- Maria Efenesia Baffa (ORCID: https://orcid.org/0000-0001-8454-7617)
- Emiliano Antiga (ORCID: https://orcid.org/0000-0001-7787-4433)
- Giuseppe Rubens Pascucci (ORCID: https://orcid.org/0000-0002-5978-1193)
- Roberto Maglie (ORCID: https://orcid.org/0000-0002-5106-4042)
- Alessandro Pucci
- Donato Amodio (ORCID: https://orcid.org/0000-0003-4550-3018)
- Alessandra Cartocci (ORCID: https://orcid.org/0000-0002-1818-6275)
- Romina Nassini (ORCID: https://orcid.org/0000-0002-9223-8395)
- Francesco De Logu (ORCID: https://orcid.org/0000-0001-8360-6929)
- Pietro Rubegni (ORCID: https://orcid.org/0000-0002-7762-9312)
- Azzurra Sirchio
- Giulia Vallini (ORCID: https://orcid.org/0009-0005-3461-2712)
- Lorenzo Bonacchi (ORCID: https://orcid.org/0009-0004-9083-6086)
- Lucrezia Timotei (ORCID: https://orcid.org/0009-0008-9268-9138)
- Caterina Giorgia Focacci
Institutions
- University of Siena (IT)
- Università Cattolica del Sacro Cuore (IT)
- University of Rome Tor Vergata (IT)
- Ambiente Italia (Italy) (IT)
- University of Florence (IT)
- Ludwig-Maximilians-Universität München (DE)
Publication Details
- Journal
- Journal of the European Academy of Dermatology and Venereology
- Published
- 2025-12-14
- DOI
- https://doi.org/10.1111/jdv.70252
- Primary Topic
- Autoimmune Bullous Skin Diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.00