Ameliorative effects and mechanism of Panax notoginseng extract on ulcerative colitis mice based on a multi-omics strategy

The results of this study demonstrate that <i>Panax notoginseng</i> extract exerts its therapeutic effects on UC by repairing the intestinal barrier, modulating the composition of the intestinal microbiota, and influencing the host metabolic profile. Multi-omics correlation analysis further revealed the central role of the microbiota-metabolite-barrier axis in the anti-UC effects of <i>Panax notoginseng</i>, providing strong evidence for its multi-target synergistic mechanism. These findings lay the foundation for a deeper understanding of the pharmacological mechanisms of Panax notoginseng in UC treatment and support its further development as a potential therapeutic agent for UC.