Dietary interventions and nutritional strategies for menopausal health: a mini review

Menopause constitutes a pivotal physiological transition characterized by irreversible cessation of ovarian function and profound estrogen depletion, precipitating vasomotor symptoms, accelerated bone resorption, heightened cardiovascular risk, and adverse metabolic reprogramming. This mini-review systematically synthesizes evidence from 42 high-quality studies (18 systematic reviews/meta-analyses and 24 randomized controlled trials) published between January 2020 and October 2025. Studies were sourced via structured searches of PubMed/MEDLINE, Scopus, Web of Science, and Cochrane Library, focusing on dietary patterns and targeted nutrient interventions in peri- and postmenopausal women (inclusion: outcomes on vasomotor symptoms, bone health, cardiovascular risk, or metabolic parameters; exclusion: hormone replacement therapy or non-human research). Narrative synthesis incorporated critical appraisal of study quality, heterogeneity, and bias. Adherence to the Mediterranean diet consistently demonstrates clinically meaningful reductions in blood pressure and triglyceride concentrations, thereby attenuating cardiovascular burden. Calcium and vitamin D co-supplementation robustly preserves bone mineral density and mitigates fracture risk. Plant-based dietary patterns rich in whole grains, fruits, and vegetables are associated with attenuated symptom severity and enhanced healthy aging trajectories. Despite these advances, postmenopausal women remain disproportionately vulnerable to micronutrient deficiencies, underscoring the imperative for balanced, nutrient-dense intake. These non-pharmacological strategies confer substantial improvements in quality of life, yet persistent gaps in long-term outcomes and representation of diverse populations necessitate further investigation.

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Journal
Frontiers in Nutrition
Published
2025-12-15
DOI
https://doi.org/10.3389/fnut.2025.1702105
Primary Topic
Menopause: Health Impacts and Treatments
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article
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article

Dietary interventions and nutritional strategies for menopausal health: a mini review

Zheng Guo, Yichen Liu
Frontiers in Nutrition
Menopause: Health Impacts and Treatments
article

Dietary interventions and nutritional strategies for menopausal health: a mini review

Zheng Guo, Yichen Liu
article en

Abstract

Menopause constitutes a pivotal physiological transition characterized by irreversible cessation of ovarian function and profound estrogen depletion, precipitating vasomotor symptoms, accelerated bone resorption, heightened cardiovascular risk, and adverse metabolic reprogramming. This mini-review systematically synthesizes evidence from 42 high-quality studies (18 systematic reviews/meta-analyses and 24 randomized controlled trials) published between January 2020 and October 2025. Studies were sourced via structured searches of PubMed/MEDLINE, Scopus, Web of Science, and Cochrane Library, focusing on dietary patterns and targeted nutrient interventions in peri- and postmenopausal women (inclusion: outcomes on vasomotor symptoms, bone health, cardiovascular risk, or metabolic parameters; exclusion: hormone replacement therapy or non-human research). Narrative synthesis incorporated critical appraisal of study quality, heterogeneity, and bias. Adherence to the Mediterranean diet consistently demonstrates clinically meaningful reductions in blood pressure and triglyceride concentrations, thereby attenuating cardiovascular burden. Calcium and vitamin D co-supplementation robustly preserves bone mineral density and mitigates fracture risk. Plant-based dietary patterns rich in whole grains, fruits, and vegetables are associated with attenuated symptom severity and enhanced healthy aging trajectories. Despite these advances, postmenopausal women remain disproportionately vulnerable to micronutrient deficiencies, underscoring the imperative for balanced, nutrient-dense intake. These non-pharmacological strategies confer substantial improvements in quality of life, yet persistent gaps in long-term outcomes and representation of diverse populations necessitate further investigation.

Frontiers in NutritionVol. 12
University of Macau (MO), Xiamen Chang Gung Hospital (CN)
Openalex Percentile: Top 47%
Menopause: Health Impacts and Treatments
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