Exploring the potential link between ADHD, anxiety, autism, and cancer risk

Neurodevelopmental and mental health disorders such as autism spectrum disorder (ASD), attention-deficit/hyperactivity disorder (ADHD), and anxiety disorders (AD) are increasingly being studied for their potential links to cancer risk. In this review, we present evidence indicating that ASD alone is not strongly associated with an increased risk of cancer. However, elevated risk is observed in subgroups with co-occurring intellectual disability or congenital anomalies. For ADHD, no direct biological link to cancer has been established, though behavioral factors and medication use remain areas of concern. Anxiety disorders may contribute indirectly to cancer risk through chronic stress and associated health behaviors, with some studies suggesting increased risk for specific cancers, such as prostate or urological cancers. Overall, this review highlights that increased cancer risk appears to be more closely related to co-occurring conditions and lifestyle factors than to the primary diagnoses themselves.

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Publication Details

Journal
Frontiers in Oncology
Published
2025-12-15
DOI
https://doi.org/10.3389/fonc.2025.1688883
Primary Topic
Attention Deficit Hyperactivity Disorder
Type
article
Field-Weighted Citation Impact
0.00
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article

Exploring the potential link between ADHD, anxiety, autism, and cancer risk

Romi Gupta, Katherine L. Ford, Shreya Wajapeyee
Frontiers in Oncology
Attention Deficit Hyperactivity Disorder
article

Exploring the potential link between ADHD, anxiety, autism, and cancer risk

Romi Gupta, Katherine L. Ford, Shreya Wajapeyee
article en

Abstract

Neurodevelopmental and mental health disorders such as autism spectrum disorder (ASD), attention-deficit/hyperactivity disorder (ADHD), and anxiety disorders (AD) are increasingly being studied for their potential links to cancer risk. In this review, we present evidence indicating that ASD alone is not strongly associated with an increased risk of cancer. However, elevated risk is observed in subgroups with co-occurring intellectual disability or congenital anomalies. For ADHD, no direct biological link to cancer has been established, though behavioral factors and medication use remain areas of concern. Anxiety disorders may contribute indirectly to cancer risk through chronic stress and associated health behaviors, with some studies suggesting increased risk for specific cancers, such as prostate or urological cancers. Overall, this review highlights that increased cancer risk appears to be more closely related to co-occurring conditions and lifestyle factors than to the primary diagnoses themselves.

Frontiers in OncologyVol. 15
University of Alabama at Birmingham Hospital (US), University of Alabama at Birmingham (US)
Openalex Percentile: Top 53%
Attention Deficit Hyperactivity Disorder
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Exploring the potential link between ADHD, anxiety, autism, and cancer risk — Romi Gupta, Katherine L. Ford, et al. · Frontiers in Oncology (2025) | TGRS Research Map | TGRS