Identifying sepsis susceptibility genes in post-surgical patients using an artificial intelligence approach
The combination of GWAS and XAI prioritized loci associated with post-operative sepsis susceptibility. The determination of key genes, such as <i>PRIM2</i>, <i>SYNPR</i>, and <i>RBSN</i>, through pre-operative blood tests could enhance risk stratification, enable early detection of post-operative sepsis, and guide targeted interventions to improve patient outcomes. Further research with additional and ethnically diverse cohorts comprising sepsis and non-sepsis patients undergoing major surgery is needed to validate these exploratory findings.
Authors
- Mario Lorenzo‐López
- Hugo Gonzalo‐Benito (ORCID: https://orcid.org/0000-0001-8340-9909)
- Álvaro Tamayo-Velasco (ORCID: https://orcid.org/0000-0001-6202-5420)
- Salvador Resino (ORCID: https://orcid.org/0000-0001-8783-0450)
- Marta Martín-Fernández (ORCID: https://orcid.org/0000-0003-2714-8120)
- Amanda Fernández‐Rodríguez (ORCID: https://orcid.org/0000-0002-5110-2213)
- Inés Quintela (ORCID: https://orcid.org/0000-0002-0239-7975)
- Raquel Cruz
- J. Álvarez (ORCID: https://orcid.org/0000-0001-6806-6944)
- Fernando Vaquerizo-Villar (ORCID: https://orcid.org/0000-0002-5898-2006)
- Aurora Baluja (ORCID: https://orcid.org/0000-0002-5204-0771)
- Tamara Hernández-Beeftink
- Roberto Hornero (ORCID: https://orcid.org/0000-0001-9915-2570)
- E Suarez-Pajes
- Sonia Veiras
- Eduardo Tamayo (ORCID: https://orcid.org/0000-0001-8900-0944)
- María Heredia‐Rodríguez (ORCID: https://orcid.org/0000-0003-3691-0252)
- Pedro Martínez-Paz (ORCID: https://orcid.org/0000-0002-5772-8153)
- Ãngel Carracedo (ORCID: https://orcid.org/0000-0003-1085-8986)
- María Ángeles Jiménez‐Sousa (ORCID: https://orcid.org/0000-0002-1945-6169)
- Laura Martínez-Campelo
- Rocío López-Herrero (ORCID: https://orcid.org/0000-0002-0295-7071)
- Adrián García-Concejo
- Jesús Villar (ORCID: https://orcid.org/0000-0001-5687-3562)
- Miguel Bardají-Carrillo (ORCID: https://orcid.org/0000-0003-1286-2591)
- Esther Gómez‐Sánchez
- Laura Sánchez-de-Prada
Institutions
- Universidad de Valladolid (ES)
- Universidade da Coruña (ES)
- St. Michael's Hospital (CA)
- University of Leicester (GB)
- Queen Mary University of London (GB)
- Universidade de Santiago de Compostela (ES)
- Instituto de Salud Carlos III (ES)
- Hospital Universitario Nuestra Señora de Candelaria (ES)
- Universidad Fernando Pessoa Canarias (ES)
- Complejo Hospitalario Universitario de Santiago (ES)
- Hospital Universitario de Gran Canaria Doctor Negrín (ES)
- Centro de Investigación Biomédica en Red de Enfermedades Respiratorias (ES)
- Instituto Tecnológico y de Energías Renovables (ES)
- Centro Nacional de Microbiologia (ES)
- Biomedical Research Networking Center in Bioengineering, Biomaterials and Nanomedicine (ES)
- Centro de Investigación Biomédica en Red (ES)
- Fundación Pública Galega de Medicina Xenómica (ES)
- Instituto de Investigación Sanitaria de Santiago (ES)
- William Harvey Research Institute (GB)
- Hospital Clínico Universitario de Valladolid (ES)
- Instituto de Investigación de Enfermedades Raras (ES)
Publication Details
- Journal
- Frontiers in Medicine
- Published
- 2025-12-15
- DOI
- https://doi.org/10.3389/fmed.2025.1644800
- Primary Topic
- Sepsis Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00