Comparative gastric microbiota profiles in non-ulcer dyspepsia and peptic ulcer patients
The absence of H. pylori in gastric disorders was linked to a notable shift in microbiota composition, with increased representation of oral-origin bacteria such as Alloprevotella, Porphyromonas, and Neisseria. These findings, observed in a Turkish patient cohort, may reflect a potentially compensatory or opportunistic microbial shift in H. pylori-negative gastroduodenal disease. As exploratory findings, this study represents the first analysis from Türkiye comparing gastric microbiota profiles in NUD and PUD patients and provides novel regional insight into gastric microbial ecology.
Authors
- Pelin Yüksel Mayda (ORCID: https://orcid.org/0000-0002-6998-5421)
- Gökhan Adaş (ORCID: https://orcid.org/0000-0002-7777-8887)
- Kıvanç Derya Peker (ORCID: https://orcid.org/0000-0002-8887-3505)
- Özer Akgül (ORCID: https://orcid.org/0000-0002-3802-3270)
- Reyhan Çalışkan (ORCID: https://orcid.org/0000-0002-2764-1823)
- Yaşar Ali Öner (ORCID: https://orcid.org/0000-0001-7397-6539)
- Burcu Sapmaz (ORCID: https://orcid.org/0000-0002-4858-8777)
- Silva Polat Sari (ORCID: https://orcid.org/0000-0001-6985-0562)
- Aliye Soylu
Institutions
- Üsküdar University (TR)
- Istanbul Aydın University (TR)
- İstanbul Gelişim Üniversitesi (TR)
- Samsun University (TR)
- Bakırköy Dr.Sadi Konuk Eğitim ve Araştırma Hastanesi (TR)
- Sağlık Bilimleri Üniversitesi (TR)
- Istanbul University (TR)
- University of Health Sciences Antigua (AG)
Publication Details
- Journal
- BMC Microbiology
- Published
- 2025-12-15
- DOI
- https://doi.org/10.1186/s12866-025-04607-y
- Primary Topic
- Helicobacter pylori-related gastroenterology studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00