The Pharmacokinetics, Pharmacological Mechanisms and Clinical Application of Zhenwu Decoction
Zhenwu Decoction (ZWD) is a classical formula that has been used for centuries and has the effect of warming yang and promoting diuresis. Clinical research is widely used in urinary, circulatory, nervous, digestive, respiratory and other diseases. ZWD has anti-inflammatory, anti-oxidative stress, anti-fibrosis, immune regulation and other effects. This article elaborates on the components and pharmacokinetics of ZWD, reviews its curative effect and pharmacological action in kidney disease, heart failure, Parkinson's disease and chronic colitis in detail, and summarizes the mechanism of some compounds of ZWD in improving kidney disease. This article provides a reference value for the development and clinical application prospects of ZWD.
Authors
- Hualiang Jiang (ORCID: https://orcid.org/0000-0003-0656-6315)
- Jiuyao Zhou (ORCID: https://orcid.org/0000-0003-3477-3370)
- Beini Lao (ORCID: https://orcid.org/0000-0002-0600-143X)
- Yuan Zhou (ORCID: https://orcid.org/0000-0002-3820-1110)
- Zhijun Zeng (ORCID: https://orcid.org/0000-0002-6133-7075)
- Yiwen Cao (ORCID: https://orcid.org/0000-0002-3108-3596)
- Jie Ma (ORCID: https://orcid.org/0000-0002-2175-8211)
- Yi‐An Liao
Institutions
- Guangzhou University of Chinese Medicine (CN)
- Guangzhou Liwan District Traditional Chinese Medicine Hospital (CN)
Publication Details
- Journal
- Basic & Clinical Pharmacology & Toxicology
- Published
- 2025-12-14
- DOI
- https://doi.org/10.1111/bcpt.70174
- Primary Topic
- Traditional Chinese Medicine Analysis
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- China Postdoctoral Science Foundation
- Natural Science Foundation of Guangdong Province