Early start of opicapone in Parkinson’s disease: evidence from a pooled analysis of phase 3 trials for sustained benefit in patients with recent onset of motor fluctuations
Early initiation of opicapone in PD patients with recently diagnosed motor fluctuations leads to sustained reductions in OFF-time and improvements in ON-time, without increasing dyskinesia or requiring escalation of levodopa doses. These exploratory findings support revising treatment strategies to include earlier use of opicapone, maximizing long-term benefits for patients with fluctuating PD.
Authors
- Helena C. Brigas (ORCID: https://orcid.org/0000-0002-4176-6649)
- Joaquim José Ferreira (ORCID: https://orcid.org/0000-0003-3950-5113)
- Georg Ebersbach (ORCID: https://orcid.org/0000-0003-3403-6987)
- Miguel M. Fonseca (ORCID: https://orcid.org/0000-0003-4598-670X)
- Fabrizio Stocchi (ORCID: https://orcid.org/0000-0002-5763-0033)
- Angelo Antonini (ORCID: https://orcid.org/0000-0003-1040-2807)
- Olivier Rascol (ORCID: https://orcid.org/0000-0002-1410-6397)
- Werner Poewe (ORCID: https://orcid.org/0000-0003-4367-0971)
- Jaime Kulisevsky (ORCID: https://orcid.org/0000-0003-4870-1431)
- José‐Francisco Rocha (ORCID: https://orcid.org/0000-0003-2611-4850)
- Daniel Ramos
- Joerg Holenz
Institutions
- Bial (Portugal) (PT)
- University of Padua (IT)
- University of Lisbon (PT)
- Innsbruck Medical University (AT)
- Vita-Salute San Raffaele University (IT)
- Inserm (FR)
- Université Fédérale de Toulouse Midi-Pyrénées (FR)
- Universität Innsbruck (AT)
- Hospital de Sant Pau (ES)
- San Raffaele University of Rome (IT)
- Biomedical Research Networking Center on Neurodegenerative Diseases (ES)
- LEA Networks (France) (FR)
- Instituto Superior Politécnico do Oeste (PT)
- Neurologisches Fachkrankenhaus für Bewegungsstörungen/Parkinson (DE)
- IRCCS San Camillo Hospital (IT)
- French Clinical Research Infrastructure Network (FR)
Publication Details
- Journal
- Frontiers in Neurology
- Published
- 2025-12-15
- DOI
- https://doi.org/10.3389/fneur.2025.1715748
- Primary Topic
- Parkinson's Disease Mechanisms and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00