A diet-induced obese and diabetic host phenotype reduces mosquito ZIKV infections and remodels gut metabolism
These findings demonstrate that the host's metabolic state is a critical modulator of mosquito physiology, increasing mosquito mortality while reducing ZIKV infection levels. This highlights that host-centric factors, such as the rising prevalence of metabolic syndrome, are an overlooked variable that may have complex epidemiological consequences for arbovirus transmission by mosquitoes.
Authors
- Anderson de Mendonça Amarante
- Isabela Ramos (ORCID: https://orcid.org/0000-0003-0874-7902)
- Mileane Busch
- Jéssica Pereira (ORCID: https://orcid.org/0000-0002-5642-414X)
- Kildare Miranda (ORCID: https://orcid.org/0000-0001-9799-773X)
- Tatiana El‐Bacha (ORCID: https://orcid.org/0000-0003-0809-0218)
- Fabio M. Gomes (ORCID: https://orcid.org/0000-0001-8439-8762)
- Patrícia Zancan (ORCID: https://orcid.org/0000-0002-0503-028X)
- Mauro Sola‐Penna (ORCID: https://orcid.org/0000-0001-9796-6829)
- Daniel Andrade Moreira (ORCID: https://orcid.org/0000-0002-9434-9582)
- Ana Beatriz Walter‐Nuno (ORCID: https://orcid.org/0000-0002-0399-3840)
- Geórgia C. Atella
- Thiago Estevam Parente (ORCID: https://orcid.org/0000-0001-7501-726X)
- Gabriela O. Paiva‐Silva (ORCID: https://orcid.org/0000-0003-3835-5416)
- Emylle Costa-Bartuli (ORCID: https://orcid.org/0000-0003-0334-5357)
- Nathan Kistenmacker
- Ana Paula Guzman Mendez
- Alexandre Menezes
- Pâmela Huaman
Institutions
- Universidade Federal do Rio de Janeiro (BR)
- Instituto Nacional de Ciência e Tecnologia em Entomologia Molecular (BR)
- Fundação Oswaldo Cruz (BR)
- Universidade Federal do Estado do Rio de Janeiro (BR)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-12-15
- DOI
- https://doi.org/10.3389/fimmu.2025.1704301
- Primary Topic
- Invertebrate Immune Response Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00