Aging-associated transcriptional programs in T cells signify constituents of TGF-β signaling for immunosenescence
Our study used systematic approaches for delineating age-dependent transcriptional networks for T-cell-associated immunosenescence. We identified multiple components of the TGF-β signaling pathway as potential biomarkers of Temra, which are strongly associated with senescence features including impaired differentiation plasticity, high cytotoxicity, and inflammatory chemotaxis capacity.
Authors
- Oscar Junhong Luo (ORCID: https://orcid.org/0000-0002-1266-3069)
- Chanchan Xiao (ORCID: https://orcid.org/0000-0001-7135-9051)
- Renke He (ORCID: https://orcid.org/0000-0003-1669-8303)
- Guobing Chen
- Yangqiu Li (ORCID: https://orcid.org/0000-0002-0974-4036)
- Wen Lei (ORCID: https://orcid.org/0000-0002-7649-2449)
Institutions
- Jinan University (CN)
- Ministry of Education (ME)
- First Affiliated Hospital of Jinan University (CN)
Publication Details
- Journal
- BMC Biology
- Published
- 2025-12-15
- DOI
- https://doi.org/10.1186/s12915-025-02484-5
- Primary Topic
- Telomeres, Telomerase, and Senescence
- Type
- article
- Field-Weighted Citation Impact
- 0.00