Immunologic Evaluation of First and Second Doses of <scp>SARS‐CoV‐2 XBB.1.5</scp> and the <scp>KP.2</scp> Monovalent Booster Vaccines in Nursing Home Residents
NHRs who received a two-dose regimen of the XBB.1.5 vaccine demonstrated stronger immune responses and higher pre-KP.2 titers than those who received a single dose. However, the diminished cross-protective neutralization of KP.2 highlights the variant's immune evasiveness. The KP.2 booster effectively elicited anti-KP.2 levels, supporting the continued use of updated, variant-matched boosters to protect high-risk populations such as NHRs.
Authors
- Eunice Lim (ORCID: https://orcid.org/0000-0002-3196-1205)
- Lisa Han (ORCID: https://orcid.org/0000-0002-9451-084X)
- Debbie Keresztesy
- Christopher L. King (ORCID: https://orcid.org/0000-0003-3873-7860)
- Yasin Abul (ORCID: https://orcid.org/0000-0001-7062-6920)
- Clare Nugent
- Irina Suley Tirado Pérez (ORCID: https://orcid.org/0000-0002-9995-3287)
- Stefan Gravenstein (ORCID: https://orcid.org/0000-0001-6000-6859)
- Laurel Holland (ORCID: https://orcid.org/0009-0008-3843-6332)
- Evan Dickerson (ORCID: https://orcid.org/0000-0002-1915-4339)
- Alejandro B. Balazs (ORCID: https://orcid.org/0000-0002-1767-3944)
- Oladayo A. Oyebanji (ORCID: https://orcid.org/0000-0001-5028-7474)
- Brigid Wilson (ORCID: https://orcid.org/0000-0003-2966-2940)
- David H. Canaday (ORCID: https://orcid.org/0000-0001-5503-7888)
- Jürgen Bosch (ORCID: https://orcid.org/0000-0002-2624-4105)
- Ellen See
- H. Edward Davidson (ORCID: https://orcid.org/0000-0002-7924-0140)
- Tiffany A. Wallace (ORCID: https://orcid.org/0000-0001-6995-8725)
- Olajide J Olagunju (ORCID: https://orcid.org/0009-0001-8018-4326)
- Chia Jung Li
- Mike Payne
Institutions
- Rhode Island Hospital (US)
- Ragon Institute of MGH, MIT and Harvard (US)
- Providence VA Medical Center (US)
- Louis Stokes Cleveland VA Medical Center (US)
- Center for Global Health (US)
- Insight Therapeutics (US)
- Case Western Reserve University (US)
Publication Details
- Journal
- Journal of the American Geriatrics Society
- Published
- 2025-12-14
- DOI
- https://doi.org/10.1111/jgs.70243
- Primary Topic
- SARS-CoV-2 and COVID-19 Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Centers for Disease Control and Prevention