Positive modulation of sigma-1 receptor: a new weapon to mitigate disease progression in amyotrophic lateral sclerosis
We here emphasize the therapeutic value of S1R activation in mitigating ALS pathology. Additionally, we show that the positive modulators pave the way for the development of new S1R-activating compounds for ALS treatment.
Authors
- Kenneth P. DuBois (ORCID: https://orcid.org/0009-0002-0381-4694)
- Julien Le Friec (ORCID: https://orcid.org/0000-0002-3232-0469)
- Tahar Ayad (ORCID: https://orcid.org/0000-0003-4210-5997)
- Nicolas Cubedo
- David Virieux (ORCID: https://orcid.org/0000-0002-6495-9478)
- Tangui Maurice (ORCID: https://orcid.org/0000-0002-4074-6793)
- Christelle Lasbleiz
- Jean-Charles Liévens (ORCID: https://orcid.org/0000-0002-0139-2291)
- Tsung‐Ping Su (ORCID: https://orcid.org/0000-0003-2384-6925)
- Simon Couly (ORCID: https://orcid.org/0000-0003-2248-1151)
- Johann Meunier (ORCID: https://orcid.org/0000-0003-1320-9391)
- Benjamin Delprat (ORCID: https://orcid.org/0000-0002-2457-6923)
- Hugo Mourier
- Arnaud De Zordo-Banliat
Institutions
- École Nationale Supérieure de Chimie de Montpellier (FR)
- Centre National de la Recherche Scientifique (FR)
- National Institute on Drug Abuse (US)
- Inserm (FR)
- École Pratique des Hautes Études (FR)
- Université de Montpellier (FR)
- Université Paris Sciences et Lettres (FR)
- Institut Charles Gerhardt Montpellier (FR)
Publication Details
- Journal
- Translational Neurodegeneration
- Published
- 2025-12-15
- DOI
- https://doi.org/10.1186/s40035-025-00527-z
- Primary Topic
- Pharmacological Receptor Mechanisms and Effects
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- French Muscular Dystrophy Association