Thromboelastometric assessment of the haemostatic effect of tranexamic acid as an adjunct to prophylactic platelet transfusions in patients with haematological malignancies undergoing intensive chemotherapy: A pilot study
Platelet transfusion as well as TXA decreased fibrinolysis for this patient population. This could be explained by the plasminogen activator inhibitor 1 contained in platelets. Future research should explore other alternative treatments and the utility of viscoelastometric testing to guide platelet transfusions, particularly in cases of bleeding or platelet transfusion refractoriness.
Authors
- Emmanuelle Tavernier (ORCID: https://orcid.org/0000-0002-1447-8721)
- Audrey Tientcheu
- Élisabeth Daguenet (ORCID: https://orcid.org/0000-0002-6101-1016)
- Thomas Lecompte (ORCID: https://orcid.org/0000-0003-3269-6156)
- Jérôme Cornillon (ORCID: https://orcid.org/0000-0001-9830-8940)
- Thomas Fatrara
- Émilie Chalayer (ORCID: https://orcid.org/0000-0003-0879-6261)
- Corinne Frère
- Bernard Tardy
- Guillaume Simoens
Institutions
- Inserm (FR)
- Sorbonne Université (FR)
- Centre Hospitalier Régional et Universitaire de Nancy (FR)
- Pitié-Salpêtrière Hospital (FR)
- Hôpital Charles-Foix (FR)
- Centre Hospitalier Universitaire de Saint-Étienne (FR)
- Université Jean Monnet (FR)
- Université de Lorraine (FR)
Publication Details
- Journal
- Vox Sanguinis
- Published
- 2025-12-14
- DOI
- https://doi.org/10.1111/vox.70165
- Primary Topic
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Type
- article
- Field-Weighted Citation Impact
- 0.00