Critical role of the mast cell/tryptase/PAR2 axis in anastrozole‐induced pain
Our results provide a new mechanism underlying anastrozole-induced pain, highlighting the mast cell/tryptase/PAR2 axis as a therapeutic target to manage painful symptoms.
Authors
- Sara Marchesan Oliveira (ORCID: https://orcid.org/0000-0003-2960-5284)
- Raquel Tonello (ORCID: https://orcid.org/0000-0002-2175-9804)
- Evelyne da Silva Brum (ORCID: https://orcid.org/0000-0001-6020-8274)
- Georg Becker (ORCID: https://orcid.org/0009-0007-9784-1111)
- Nigel W. Bunnett (ORCID: https://orcid.org/0000-0003-3367-0644)
- Maria Fernanda Pessano Fialho (ORCID: https://orcid.org/0000-0001-8899-2099)
Institutions
- Universidade Federal do Rio Grande do Sul (BR)
- Universidade Federal de Santa Maria (BR)
- New York University (US)
Publication Details
- Journal
- British Journal of Pharmacology
- Published
- 2025-12-14
- DOI
- https://doi.org/10.1111/bph.70280
- Primary Topic
- Mast cells and histamine
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- U.S. Department of Defense
- Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
- Conselho Nacional de Desenvolvimento Científico e Tecnológico
- National Institutes of Health