CXCL5 neutralization mitigates cancer cachexia by disrupting CAF-cancer cell crosstalk
CAF contribute to cachexia via cancer cell crosstalk that upregulates CXCL5 secretion. CXCL5 neutralization offers a novel therapeutic approach to maintain muscle mass in cancer patients.
Authors
- Seon Wook Kim (ORCID: https://orcid.org/0000-0001-6555-1741)
- Darren R. Williams (ORCID: https://orcid.org/0000-0003-2555-3069)
- Jung‐Joon Min (ORCID: https://orcid.org/0000-0001-6358-2798)
- Sang Hoon Lee (ORCID: https://orcid.org/0000-0002-3619-4340)
- Hyunju Lee (ORCID: https://orcid.org/0000-0003-2389-7183)
- Jun-Hyeong Kim
- Sooyoung Lee (ORCID: https://orcid.org/0000-0003-1734-4101)
- Hyun‐Jun Kim (ORCID: https://orcid.org/0000-0001-9254-394X)
- Da‐Woon Jung (ORCID: https://orcid.org/0000-0001-6005-0833)
- Sanghee Cho (ORCID: https://orcid.org/0000-0001-6715-9348)
- Kyoung‐Hwan Joo
Institutions
- Gwangju Institute of Science and Technology (KR)
- Chonnam National University Hwasun Hospital (KR)
Publication Details
- Journal
- Journal of Biomedical Science
- Published
- 2025-12-15
- DOI
- https://doi.org/10.1186/s12929-025-01192-0
- Primary Topic
- Muscle Physiology and Disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00