Predictors of vertebral fractures in patients with severe osteoporosis: a sub-analysis of the Japanese Osteoporosis Intervention Trial-05 (JOINT-05)
Beyond established risk factors such as pre-existing fractures, this study identified the allocation of osteoporosis treatment, low serum triglyceride levels, and the intensity of low back pain as independent predictors of new VFs in high-risk elderly women. Thus, clinical strategies to prevent subsequent fractures should include optimizing pharmacological treatment (e.g., sequential therapy with teriparatide), considering lipid status, and implementing effective, multimodal pain management.
Authors
- Hiroshi Hagino (ORCID: https://orcid.org/0000-0001-8053-1095)
- Satoshi Mori (ORCID: https://orcid.org/0000-0002-7660-5562)
- Hiroyuki Inose (ORCID: https://orcid.org/0000-0003-4195-2545)
- Shiro Tanaka (ORCID: https://orcid.org/0000-0001-6817-5235)
- Satoshi Soen (ORCID: https://orcid.org/0000-0002-0955-2747)
Institutions
- Kyoto University (JP)
- Seirei Hamamatsu General Hospital (JP)
- Dokkyo Medical University Saitama Medical Center (JP)
- Bone Health and Osteoporosis Foundation (US)
- Sanin Rosai Hospital (JP)
Publication Details
- Journal
- Archives of Osteoporosis
- Published
- 2025-12-14
- DOI
- https://doi.org/10.1007/s11657-025-01649-7
- Primary Topic
- Bone health and osteoporosis research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Amgen
- Eli Lilly and Company
- Ministry of Health, Labour and Welfare
- Ministry of Education, Science and Technology
- Novo Nordisk
- Daiichi Sankyo Europe