Predicting Ventricular Arrhythmia in Myocardial Ischemia Using Machine Learning

Ventricular arrhythmia frequently complicates myocardial ischemic events, sometimes to devastating ends. Accurate arrhythmia prediction in this setting could improve outcomes, yet traditional models struggle with the temporal complexity of the data. This study employs a Long Short-Term Memory (LSTM) network to predict the time to the next premature ventricular contraction (PVC) using high-resolution experimental data. We analyzed electrograms from 11 large animal experiments, identifying 1832 PVCs, and computed time-to-PVC. An LSTM model (247 inputs, 1024 hidden units) was trained on 10 experiments, with one held out for testing, achieving a validation MAE of 8.6 seconds and a test MAE of 135 seconds (loss 68.5). Scatter plots showed strong validation correlation and a positive test trend, suggesting the potential of this approach.