Copper-Catalyzed Stereoselective Synthesis of Fluorinated 1,3-Dienes via Sequential Iodine–Fluorine Elimination

We report a copper-catalyzed stereoselective synthesis of fluorinated 1,3-dienes from unactivated alkenes via base-promoted sequential iodine-fluorine elimination. This protocol leverages commercially available polyfluoroalkyl iodides and β,γ-unsaturated amides to deliver structurally diverse fluoro-dienes with excellent selectivity and broad functional group tolerance, including complex natural product derivatives. This method provides efficient access to previously challenging fluorinated conjugated systems, offering a versatile platform for fluorine-containing molecular design in pharmaceuticals and materials.