Robot‐Assisted Reconstruction and Control of the Pechmann Reaction Network
A robotic platform was deployed to map the distributions of products and by-products of the classic Pechmann reaction over a four-dimensional "hyperspace" of conditions. This systematic scan reveals the presence of 15 products of which 11 are unprecedented, including those forming by unusual mechanistic routes. In turn, the knowledge of the hyperspace allows for the deduction of causal relationships between the forming species, ultimately enabling the reconstruction of the underlying reaction network. The hyperspace approach provides a more complete description of organic reactions as dynamic networks which, depending on conditions, can be steered toward different outcomes.
Authors
- Wai‐Shing Wong (ORCID: https://orcid.org/0000-0002-8705-9392)
- Peter Richard Schreiner (ORCID: https://orcid.org/0000-0002-3608-5515)
- Diana V. Kolygina (ORCID: https://orcid.org/0000-0003-2664-6072)
- Yankai Jia (ORCID: https://orcid.org/0000-0003-0586-3473)
- Bibek Prajapati (ORCID: https://orcid.org/0000-0001-6092-9901)
- Benito Marazzi (ORCID: https://orcid.org/0000-0001-7077-1394)
- Rafał Frydrych (ORCID: https://orcid.org/0000-0002-1365-4690)
- Nikolaos Vagkidis (ORCID: https://orcid.org/0000-0001-7087-0739)
- Bartosz A. Grzybowski (ORCID: https://orcid.org/0000-0001-6613-4261)
Institutions
- Justus-Liebig-Universität Gießen (DE)
- Ulsan National Institute of Science and Technology (KR)
Publication Details
- Journal
- Angewandte Chemie International Edition
- Published
- 2025-12-12
- DOI
- https://doi.org/10.1002/anie.202518394
- Citations
- 1
- Primary Topic
- Cyclization and Aryne Chemistry
- Type
- article
- Field-Weighted Citation Impact
- 0.94
Funders
- European Commission