Efficacy and safety of a single intra-articular injection of mannitol-combined hyaluronan in patients with knee osteoarthritis – A double-blinded randomized clinical study
A single injection of JETKNEE did not show superiority to placebo in the primary outcome (VAS pain), but demonstrated improvements in secondary functional outcomes for 6 months in patients with knee OA.
Authors
- I‐Hsiu Liou (ORCID: https://orcid.org/0000-0001-7754-2957)
- Shu‐Fen Sun (ORCID: https://orcid.org/0000-0003-0534-5115)
- Cheng‐Chang Lu (ORCID: https://orcid.org/0000-0002-7194-9147)
- Ming-Hsuan Huang
- Ruei-Sian Ding (ORCID: https://orcid.org/0000-0003-2813-8610)
- Chun-Yu Chen (ORCID: https://orcid.org/0000-0001-6213-0853)
Institutions
- Kaohsiung Medical University (TW)
- Kaohsiung Veterans General Hospital (TW)
Publication Details
- Journal
- The Knee
- Published
- 2025-12-11
- DOI
- https://doi.org/10.1016/j.knee.2025.11.018
- Primary Topic
- Osteoarthritis Treatment and Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00