Diazepam modulates anterior cingulate glutamate levels in people at clinical high-risk for psychosis
These findings suggest that pharmacological modulation of GABAA receptors can alter Glx changes in and support a novel therapeutic mechanism of benefit for individuals at clinical high risk of psychosis.
Authors
- Maria Antonietta Nettis (ORCID: https://orcid.org/0000-0002-5401-8391)
- Gemma Modinos (ORCID: https://orcid.org/0000-0002-7870-066X)
- Nicholas R Livingston (ORCID: https://orcid.org/0000-0002-6582-2545)
- Anthony A. Grace (ORCID: https://orcid.org/0000-0003-1864-5504)
- Luke A. Jelen (ORCID: https://orcid.org/0000-0001-6398-5239)
- Thomas J. Reilly (ORCID: https://orcid.org/0000-0001-6890-918X)
- Cecilia Casetta (ORCID: https://orcid.org/0000-0002-1980-3415)
- Steven Williams (ORCID: https://orcid.org/0000-0003-4299-1941)
- Cathy Davies (ORCID: https://orcid.org/0000-0003-3011-8643)
- James Stone (ORCID: https://orcid.org/0000-0003-3051-0135)
- Amanda Kiemes (ORCID: https://orcid.org/0000-0001-6819-8090)
- Samuel Knight (ORCID: https://orcid.org/0000-0003-3420-3722)
- Paolo Fusar‐Poli (ORCID: https://orcid.org/0000-0003-3582-6788)
- Alice Egerton (ORCID: https://orcid.org/0000-0003-2939-064X)
- Paulina B. Lukow (ORCID: https://orcid.org/0000-0002-6796-9102)
- Thomas Spencer (ORCID: https://orcid.org/0000-0001-5661-3293)
- Andrea De Micheli (ORCID: https://orcid.org/0000-0002-8358-5715)
- David J. Lythgoe (ORCID: https://orcid.org/0000-0002-5078-9025)
- Philip K. McGuire (ORCID: https://orcid.org/0000-0003-4381-0532)
- Aikaterini Dima (ORCID: https://orcid.org/0000-0002-6371-775X)
Institutions
- Brighton and Sussex Medical School (GB)
- University of Sussex (GB)
- Wellcome Centre for Human Neuroimaging (GB)
- University of Pittsburgh (US)
- King's College London (GB)
- South London and Maudsley NHS Foundation Trust (GB)
- University of Pavia (IT)
- University of Oxford (GB)
- University College London (GB)
- Ludwig-Maximilians-Universität München (DE)
Publication Details
- Journal
- The International Journal of Neuropsychopharmacology
- Published
- 2025-12-12
- DOI
- https://doi.org/10.1093/ijnp/pyaf078
- Primary Topic
- Neuroscience and Neuropharmacology Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Wellcome Trust
- National Institute for Health and Care Research
- Royal Society
- NIHR Maudsley Biomedical Research Centre