Impacts of polymorphisms in drug-metabolizing enzyme and transporter genes on irinotecan toxicity and efficacy in Thai colorectal cancer patients
UGT1A1*6 and ABCC2 -24C > T variants emerge as potential predictors of irinotecan-induced neutropenia, while UGT1A1*6 and SLCO1B1 521T > C may serve as markers of prolonged PFS in Thai patients. Validation through larger prospective studies is essential to confirm and refine these genetic associations.
Authors
- Chalirmporn Atasilp
- Natchaya Vanwong (ORCID: https://orcid.org/0000-0002-2230-3593)
- Patompong Satapornpong
- Chonlaphat Sukasem (ORCID: https://orcid.org/0000-0003-0033-5321)
- Rattanaporn Sukprasong (ORCID: https://orcid.org/0000-0002-2465-8558)
- Pimonpan Jinda (ORCID: https://orcid.org/0000-0003-2581-2577)
- Natthakul Akarapredee
- Jiraporn Jensuriyarkun
- Soravit Wongjitjanyong
Institutions
- Thammasat University (TH)
- Chulalongkorn University (TH)
- Mahidol University (TH)
- Ramathibodi Hospital (TH)
- Rangsit University (TH)
Publication Details
- Journal
- PLoS ONE
- Published
- 2025-12-12
- DOI
- https://doi.org/10.1371/journal.pone.0338442
- Primary Topic
- Cancer therapeutics and mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Chulalongkorn University
- Mahidol University
- Thailand Science Research and Innovation