Astrocyte S1P1 regulates mitochondrial autophagy in inflammation and neuronal injury after epilepsy
S1P1-PHB2 axis plays a crucial role in the neuroinflammation and neurodamage caused by epilepsy. S1P1, through PHB2, promotes mitochondrial autophagy, increases oxidative stress and releases pro-inflammatory cytokines, thereby leading to neural damage. By using the S1P1 antagonist W146 to inhibit autophagy and inflammatory responses, these effects can be alleviated.
Authors
- J.F. Shao (ORCID: https://orcid.org/0000-0002-6632-8207)
- Weiyi Huang (ORCID: https://orcid.org/0000-0002-7992-3005)
- Jun Sun (ORCID: https://orcid.org/0000-0003-4346-6313)
- Zhaodi Liao (ORCID: https://orcid.org/0000-0002-5387-732X)
- Chao Cheng (ORCID: https://orcid.org/0000-0003-3234-5874)
- Qijian Zhang (ORCID: https://orcid.org/0000-0003-2785-0972)
- Yuanrun Zhu
- Weifeng Miao
- L.F. Yang (ORCID: https://orcid.org/0009-0002-0058-9428)
Institutions
- Wuxi People's Hospital (CN)
- Nanjing Medical University (CN)
Publication Details
- Journal
- Neurological Research
- Published
- 2025-12-12
- DOI
- https://doi.org/10.1080/01616412.2025.2602687
- Primary Topic
- Autophagy in Disease and Therapy
- Type
- article
- Field-Weighted Citation Impact
- 0.00