Exploring the Pathogens in Primary Predominantly Antibody Deficiencies of Unknown Genetic Origin
This study highlights the predominance of recurrent and encapsulated bacterial respiratory tract infections in PAD and the underutilization of microbiological cultures. Generalized mixed-effects logistic regression best predicted BPAD. Clinicians should consider immunologic evaluation in patients presenting with serious bacterial infections, multi-system recurrent infections or the repeated isolation of encapsulated bacteria in unusually severe or recurrent infections.
Authors
- Esther de Vries (ORCID: https://orcid.org/0000-0003-4311-3550)
- Jean‐Luc Murk (ORCID: https://orcid.org/0000-0003-3661-9035)
- Roeland van Hout (ORCID: https://orcid.org/0000-0002-8870-1631)
- Eugène van Puijenbroek (ORCID: https://orcid.org/0000-0002-2236-1398)
- Barbara Bergmans
- Lisanne Fontane Pennock-Janssen
Institutions
- Radboud University Nijmegen (NL)
- University of Groningen (NL)
- Tilburg University (NL)
- Netherlands Pharmacovigilance Centre Lareb (NL)
- Elisabeth-TweeSteden Ziekenhuis (NL)
- Jeroen Bosch Ziekenhuis (NL)
Publication Details
- Journal
- Journal of Clinical Immunology
- Published
- 2025-12-12
- DOI
- https://doi.org/10.1007/s10875-025-01970-3
- Primary Topic
- Immunodeficiency and Autoimmune Disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00