Monovalent mannose‐glycoconjugates of sulforaphane reprogram human dendritic cells via NFATc1 to induce immune tolerance under inflammatory conditions
Our findings identify NFATc1 as a key transcriptional switch in moDCs tolerogenic programming and highlight the carbohydrate-dependent specificity of SFN conjugates. SFNMan represents a novel carbohydrate-engineered immunomodulator capable of driving immune tolerance through NFATc1 activation. These results provide a mechanistic framework for the development of precision therapies targeting inflammatory and autoimmune diseases.
Authors
- Francisca Palomares (ORCID: https://orcid.org/0000-0001-5591-7877)
- Macarena Martínez‐Bailén (ORCID: https://orcid.org/0000-0001-6924-5151)
- Ana Maria Múnera‐Rodríguez
- Camila Leiva‐Castro
- Ana T. Carmona (ORCID: https://orcid.org/0000-0003-1058-7127)
- Soledad López-Enríquez
- María Elena Angarita-Planchez
Institutions
- Cornell University (US)
- Hospital Universitario Virgen Macarena (ES)
- Hospital Universitario Virgen del Rocío (ES)
- Universidad de Sevilla (ES)
Publication Details
- Journal
- British Journal of Pharmacology
- Published
- 2025-12-12
- DOI
- https://doi.org/10.1111/bph.70291
- Primary Topic
- Genomics, phytochemicals, and oxidative stress
- Type
- article
- Field-Weighted Citation Impact
- 0.00