Two new phenylethanol glycosides from the roots of <i>eleutherococcus senticosus</i> (rupr. et maxim.) maxim
Twenty-six coumarin derivatives were isolated from the roots of <i>Eleutherococcus senticosus</i> (Rupr. et Maxim.) Maxim., including two new compounds, 4-ethyl-2-methoxyphenol-<i>β</i>-D-xylopyraosyl-(1″→6')-<i>β</i>-D-glucopyranoside (<b>1</b>) and 4-ethyl-2-methoxyphenol-<i>α</i>-L-rhamnopyranosyl-(1″→6')-<i>β</i>-D-glucopyranoside (<b>2</b>) and 24 known aromatic compounds (<b>3-26</b>). Structural elucidation of compounds <b>1-26</b> was confirmed by 1D and 2D NMR spectra from the literature as well as high-resolution mass spectrometric analysis. To evaluate the neuroprotective effects of all compounds on H<sub>2</sub>O<sub>2</sub>-induced injury in human neuroblastoma SH-SY5Y cell line, we conducted experiments. Compounds <b>15</b> and <b>24</b> showed significant protective against reduced viability of SH-SY5Y cells decreased by H<sub>2</sub>O<sub>2</sub>, which confirmed that they had good neuroprotective effects.
Authors
- Hui-Chen Zhu
- Wei Guan (ORCID: https://orcid.org/0000-0002-4639-9569)
- Jia‐Tong Wu (ORCID: https://orcid.org/0000-0002-1090-9766)
- Ke Xiao (ORCID: https://orcid.org/0000-0002-6599-7118)
- Mengmeng Li (ORCID: https://orcid.org/0000-0003-3967-8372)
- Yan Liu (ORCID: https://orcid.org/0000-0003-3677-9290)
- Haixue Kuang (ORCID: https://orcid.org/0000-0003-2836-5768)
- Haolin Yang
- Juan Pan
- Siyi Wang (ORCID: https://orcid.org/0009-0006-4909-2569)
Institutions
- Beijing University of Chinese Medicine (CN)
- Heilongjiang University of Chinese Medicine (CN)
Publication Details
- Journal
- Natural Product Research
- Published
- 2025-12-12
- DOI
- https://doi.org/10.1080/14786419.2025.2598826
- Citations
- 1
- Primary Topic
- Natural product bioactivities and synthesis
- Type
- article
- Field-Weighted Citation Impact
- 0.81