Phenotypic Analysis of Embryos in a Noonan Syndrome Model Mouse With the <i>Rit1</i> <scp>A57G</scp> Mutation
Rit1 mutation causes cardiovascular and lymphatic abnormalities in the fetal period, and that the activation of MEK/ERK is the potential pathogenesis of cardiac hypertrophy.
Authors
- Tetsuya Niihori (ORCID: https://orcid.org/0000-0002-2118-9776)
- Taiki Abe (ORCID: https://orcid.org/0000-0001-6580-3734)
- Yoko Aoki (ORCID: https://orcid.org/0000-0002-1194-6972)
- Atsuo Kikuchi (ORCID: https://orcid.org/0000-0003-1002-8739)
- Dai Suzuki (ORCID: https://orcid.org/0000-0002-9905-0774)
Institutions
- Tohoku University (JP)
Publication Details
- Journal
- Molecular Genetics & Genomic Medicine
- Published
- 2025-12-01
- DOI
- https://doi.org/10.1002/mgg3.70167
- Primary Topic
- Protein Tyrosine Phosphatases
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Japan Society for the Promotion of Science