Expression and interaction of RNA binding protein HuR with multidrug transporters (P-GP, MRP1, and ABCG2) in chemoresistant breast and colorectal cancer cells
The observed overexpression of HuR in chemoresistant tissues suggests its association with chemoresistance mechanisms. Besides, HuR might facilitate posttranscriptional mRNA stabilization of P-GP, MRP1, and ABCG2, which makes it a potential therapeutic target to improve treatment outcomes in chemoresistant patients.
Authors
- Sharif Akhteruzzaman (ORCID: https://orcid.org/0000-0002-0974-7667)
- Abu Ashfaqur Sajib (ORCID: https://orcid.org/0000-0003-1710-9865)
- Md Mahmudul Hasan Akash
- Mohammad Mostafa (ORCID: https://orcid.org/0000-0001-8886-1937)
- Sudipta Deb Nath (ORCID: https://orcid.org/0000-0001-6561-3834)
- Md Tamzid Hossain Tanim (ORCID: https://orcid.org/0000-0002-0368-0561)
Institutions
- University of Dhaka (BD)
- Dhaka Medical College and Hospital (BD)
Publication Details
- Journal
- Journal of Genetic Engineering and Biotechnology
- Published
- 2025-10-15
- DOI
- https://doi.org/10.1016/j.jgeb.2025.100594
- Citations
- 1
- Primary Topic
- RNA Research and Splicing
- Type
- article
- Field-Weighted Citation Impact
- 0.81