The Association Between Self-Reported Types of Toxic Exposures and Symptom Severity Among Gulf War Era Veterans

We found a positive association between the number of toxic exposure types and total symptom severity. Veterans who self-reported having Gulf War Illness also reported more types of toxic exposures compared with Veterans who did not report having Gulf War Illness. Radiation and biological agent exposure showed the strongest positive association with symptom scores, yet very few Veterans reported isolated exposure of these types. Our findings suggest that cumulative exposure to multiple types of toxins could be associated with the development and severity of Gulf War Illness symptoms.

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Publication Details

Journal
Medical Care
Published
2025-09-15
DOI
https://doi.org/10.1097/mlr.0000000000002212
Primary Topic
Fibromyalgia and Chronic Fatigue Syndrome Research
Type
article
Field-Weighted Citation Impact
0.00
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article

The Association Between Self-Reported Types of Toxic Exposures and Symptom Severity Among Gulf War Era Veterans

Mark Helfand, Jennifer L. Barton, Kara Winchell, Shannon M. Nugent et al.
Medical Care
Fibromyalgia and Chronic Fatigue Syndrome Research
article

The Association Between Self-Reported Types of Toxic Exposures and Symptom Severity Among Gulf War Era Veterans

Mark Helfand, Jennifer L. Barton, Kara Winchell, Shannon M. Nugent, Elizabeth R. Hooker, Molly S Phan
article en

Abstract

We found a positive association between the number of toxic exposure types and total symptom severity. Veterans who self-reported having Gulf War Illness also reported more types of toxic exposures compared with Veterans who did not report having Gulf War Illness. Radiation and biological agent exposure showed the strongest positive association with symptom scores, yet very few Veterans reported isolated exposure of these types. Our findings suggest that cumulative exposure to multiple types of toxins could be associated with the development and severity of Gulf War Illness symptoms.

Medical CareVol. 64(2S)
Oregon Health & Science University (US), VA Portland Health Care System (US)
Openalex Percentile: Top 53%
Fibromyalgia and Chronic Fatigue Syndrome Research
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