Biomimetic Total Synthesis of Dispirocochlearoids A–C and Related <i>Ganoderma</i> Meroterpenoid Dimers
The first total synthesis of the anti-inflammatory <i>Ganoderma</i> meroterpenoid dimers dispirocochlearoids A-C, along with five of their diastereomers─potential unreported natural products─has been accomplished using a convergent strategy that leveraged common intermediates derived from dayaolingzhiol M. The synthesis features several key steps: a hetero-Diels-Alder reaction, a hydrolysis/double-bond migration cascade to assemble the D/E-bicyclic core, and a condensation/intramolecular aldol/lactonization cascade that constructs the final B/C-bicyclic system of dispirocochlearoids A-C.
Authors
- Linhai Chen (ORCID: https://orcid.org/0000-0002-7152-3533)
- Xuliang Liu (ORCID: https://orcid.org/0000-0003-1726-4646)
- Fajun Nan (ORCID: https://orcid.org/0000-0002-2284-3637)
- De-Sheng Zhan
- Sheng‐Jie Shi
- Lin Yang (ORCID: https://orcid.org/0000-0002-0527-2094)
- Jianpeng Yin (ORCID: https://orcid.org/0000-0003-3310-9101)
Institutions
- Yantai University (CN)
- Chinese Academy of Sciences (CN)
- Shanghai Institute of Materia Medica (CN)
- National Center for Drug Screening (CN)
- Advanced Research Institute (US)
Publication Details
- Journal
- Organic Letters
- Published
- 2025-12-12
- DOI
- https://doi.org/10.1021/acs.orglett.5c04234
- Primary Topic
- Fungal Biology and Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.00